Saturday, April 20, 2013

CISPA, the Fourth Amendment, and you

Overshadowed by congressional action on guns and immigration is an Internet privacy bill that could affect most Americans, without them knowing it, on a daily basis.

Cyber Intelligence Sharing and Protection Act (or CISPA) is making its way through Congress, and it?s passed a House vote on Thursday.

The final vote in the House was 248-168, as 42 Democrats voted for the bill, while 28 Republicans voted against it.

And like gun control, it?s far from a done deal after the House passes CISPA. It would need Senate approval, and President Barack Obama has indicated he?ll possibly veto CISPA if it comes to his desk.

Both sides of Congress would need to muster a two-thirds majority vote to override the president?s veto, which would seem unlikely in the current political atmosphere of Washington.

At the heart of CISPA is a Fourth Amendment issue.

The amendment reads:

?The right of the people to be secure in their persons, houses, papers, and effects, against unreasonable searches and seizures, shall not be violated, and no Warrants shall issue, but upon probable cause, supported by Oath or affirmation, and particularly describing the place to be searched, and the persons or things to be seized.?

CISPA is designed to let the federal government work with private companies to fight hackers and cybercriminals in and outside of the United States. As part of the effort to detect cyber threats, private companies could voluntarily share with the government data about Internet users.

The sharing could be done in ?real time? as the cybercops try to defeat and track down the evildoers. Companies could also share data among themselves as part of the effort.

There are major drawbacks about the legislation, say CISPA?s critics. The privacy provisions for consumers, they claim, are vague or nonexistent. The government and companies can?t look at your personal data, such as medical records and tax returns, if they are part of the ?data dump? that is shared in real time. But the law doesn?t require that companies excise, or edit out, that information in the transfer process.

Another criticism is that a warrant isn?t needed for the government to obtain that information. And companies that share your information won?t be held legally liable for sharing that information, a practice that seemingly conflicts with privacy policies on existing websites.

CISPA?s biggest critic in Congress is a representative from Colorado, Jared Polis. The Democrat told the House on Wednesday, ?This is the biggest government takeover of personal information that I?ve seen during my time here in Congress.?

Mike Rogers, a Republican representative from Michigan and the House Intelligence Committee chairman, is leading the CISPA effort, along with Dutch Ruppersberger, a Democrat from Maryland.

Rogers believes the measure is long needed. ?People were stealing their identities, their accounts, their intellectual property, and subsequent to that, their jobs,? he recently said. ?[Web users] began to question the value of getting on Internet and using [it] for commercial purposes. Their trust in the free and open Internet ? was at risk.?

He has also stressed that participation in CISPA is voluntary for companies.

The Intelligence Committee also released a five-page document to counter what it calls ?myths? about CISPA, including how much personal data would be shared with the government?which it says would be a rare occurrence.

The American Civil Liberties Union, however, calls CISPA ?fatally flawed.?

?The core problem is that CISPA allows too much sensitive information to be shared with too many people in the first place, including the National Security Agency,? it says.

Unlike SOPA, the failed legislative attempt last year to halt online piracy, large tech companies are supporting the efforts to get CISPA passed.

At one time, Facebook and Microsoft had signed on to support CISPA, but now they are reportedly backing away. Google appears to be on the fence about the issue.

Major communications and utilities companies support CISPA, according to a list released by the House.

Last year, the House passed a similar CISPA bill, only to see it die in the Senate. Last August, a successful filibuster blocked CISPA from getting to the floor for a vote. Both libertarians and liberals had issues with the bill, and there were disagreements about which government agencies would be involved with CISPA.

The tea party-aligned group FreedomWorks is on record, again, as opposing CISPA on Fourth Amendment grounds.

?There are grave Fourth Amendment concerns with CISPA. The bill would override existing privacy laws to allow companies to share ?cyber threat information? with the federal government without making any reasonable effort to strip out any personal information from the file,? the group said in a statement.

The Electronic Frontier Foundation also has Fourth Amendment concerns.

?As it stands, CISPA is dangerously vague, and should not?allow for any expansion of?government powers through a series of poorly worded?definitions.??If the drafters intend to?give new powers to the government?s already extensive capacity to examine your?private?information, they should propose clear and specific language so we can?have a real debate,? the EFF said on its website.

Scott Bomboy is the editor-in-chief of the National Constitution Center.

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Source: http://news.yahoo.com/cispa-fourth-amendment-143420272.html

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Friday, April 19, 2013

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American Airlines resumes flight schedule

DALLAS (AP) -- American Airlines played catch-up Wednesday, resuming most flights and even adding a handful that weren't on the schedule to help passengers stranded by a massive technology failure that grounded the carrier's entire U.S. fleet a day earlier.

But some cancellations persisted, and delays were still common. About a third of American flights were late as of mid-afternoon.

American's CEO blamed Tuesday's breakdown on a software problem that knocked out computer systems needed for booking flights, tracking bags, loading and fueling planes and more.

"As you'd imagine, we do have redundancies in our system," Tom Horton, chief executive of parent company AMR Corp., said in an apology to passengers posted on YouTube. "But unfortunately in this case, we had a software issue that impacted both our primary and backup systems."

American and smaller-jet subsidiary American Eagle still canceled more than 300 flights by mid-afternoon, according to flight-tracking service FlightAware.com. American said some flights were affected by bad weather in Chicago.

But American's performance was a huge improvement over Tuesday, when the computer failure brought all departures to a halt. Flights already in the air were allowed to continue to their destinations, but planes on the ground could not take off.

American and American Eagle canceled nearly 1,000 flights and delayed another 1,100. Two-thirds of their scheduled flights were late or never got into the air.

On Wednesday, American added seven unscheduled flights to accommodate passengers stranded the day before in Chicago, Dallas and Los Angeles.

As marooned passengers resume their travels, questions lingered about the technology and whether American's systems will be adequate to avoid similar collapses after the company merges with US Airways to form the world's biggest airline.

AMR and US Airways hope to complete their merger by September and create a giant that would surpass current industry leader United in passenger miles. Airline mergers are always difficult, and one of the trickiest parts is combining technology systems.

When the systems of US Airways and America West Airlines were combined in 2007, chaos ensued. Hundreds of check-in kiosks didn't work, ticket agents were swamped, and flights delays lingered for days.

United's reservations system failed on several days last year after it converted to the one run by merger partner Continental Airlines. The CEO was forced to apologize.

Even if flights operate on time, there can be other hitches when systems are merged. At United, upgrades for elite members of the frequent-flier program weren't handled properly, and flights booked with miles weren't always ticketed correctly. Those mistakes were especially upsetting to the airline's most loyal customers. It's one thing for one flight to be late. For many veteran fliers, it's worse to constantly worry about upgrades.

Airline technology is notoriously complicated because so many pieces of the system rely on each other for information, said Emre Serpen, a consultant at InterVistas who works with airlines on technology issues.

Passenger information goes into the system and tells gate workers whether all the passengers have arrived. The same information is used to calculate the weight of the fully loaded plane. Flight dispatchers, who may be in a command center across the country, use the figures to order the right amount of fuel ? too much fuel adds weight and reduces mileage.

Besides performing many functions, airline computer systems might be assembled or serviced by different vendors. For American, the complexity will be magnified when it combines reservations, scheduling, frequent-flier and other programs with those at US Airways.

"They have to merge all the data from US Airways over to the American system. There could be huge translation problems" if the two airlines' systems use different coding, said Bill Curtis, senior vice president of CAST, a business software-analysis firm.

"They'll probably have some hiccups," Curtis said. "They may be big ones, or they may be so small that the public never notices."

AMR did not immediately respond to a request to make its chief information officer, Maya Leibman, available for an interview. She has been American's top technology officer for a little more than a year, replacing an executive who resigned shortly after AMR filed for bankruptcy protection in November 2011.

The term "information technology" appeared only three times in AMR's latest annual report filed with the Securities and Exchange Commission, and the company has provided few details on how much it spends to improve and maintain its computer systems, or who does all the work.

AMR said in the annual report that it has "engaged an increasing number of third-party service providers" for many jobs, including information technology hardware and services. The report also said the company will spend at least $80 million this year and $70 million in later years on a single IT-support contract.

US Airways CEO Doug Parker will run the new company after the merger. He has said he would prefer to convert his company's computer systems to American's since American is larger. He has pointed to the technology breakdowns that occurred after the United-Continental and US Airways-America West mergers, when the larger airline adopted the smaller one's systems.

For a second straight day Wednesday, US Airways declined to comment on whether Parker would reconsider his plans considering American's nationwide outage.

___

Associated Press Airlines Writer Joshua Freed in Minneapolis contributed to this report.

___

David Koenig can be reached at http://www.twitter.com/airlinewriter .

Source: http://news.yahoo.com/american-airlines-resumes-most-flights-183233970.html

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Thursday, April 18, 2013

S&P warns Russia on high costs for 2018 World Cup

MOSCOW (AP) ? Many of the Russian cities hosting the 2018 World Cup will have trouble finding the money to build soccer stadiums and improve transit links and other infrastructure, the Standard & Poor's ratings agency has warned.

Seven of the 11 Russian host cities will have to borrow money or receive much more support from the federal government than is now planned, the U.S. ratings agency said.

Unless the Russian government steps up its funding "the current poor state of municipal infrastructure in the host cities means the standards of infrastructure at tournament venues are likely to be lower than in the past," S&P said in a report.

The Russian government estimates the total 2018 World Cup budget at $22 billion, which already is much higher than Brazil's budget of $13.6 billion for the 2014 World Cup. The Russian government has also said it would restrict its World Cup support to sports-related construction.

Russia's local governments, however, have put the total cost for the 2018 World Cup at up to $43 billion, which includes new metro lines, roads, airports and utility upgrades.

But for most of them, "slowing economic growth, material spending pressure triggered by a presidential call for public salary increases and very modest fiscal flexibility" will make it difficult to find sufficient funds, Standard & Poor's said.

S&P said four Russian cities should have no trouble covering their 2018 World Cup expenditures: Moscow, St. Petersburg, Kazan and Sochi. Among the remaining seven, those facing the biggest difficulties are Kaliningrad, Samara and Saransk, it said.

Michel Platini, president of the European soccer body UEFA, met with Russian President Vladimir Putin in Sochi on Wednesday after touring some 2014 Olympic construction sites with Russia's sports minister.

"Honestly speaking, it would have been much more interesting to see the stadiums being built for the World Cup," Russian news agencies quoted Platini as saying. "In any case, I can state that the work is going ahead."

Putin thanked Platini for praising the performance of the Russian national soccer team in the 2014 World Cup qualifiers.

"To hear such an assessment from such a specialist like you is really nice," Putin said during the televised meeting.

In its report, S &P encouraged Russia's federal government to step in as it has done ahead of other international events, including the 2014 Winter Olympics in Sochi, but cautioned that Russia may find this more difficult now because of slower economic growth and higher spending.

Russian expenditures for the 2014 Sochi Olympics are estimated to eventually be about $50 billion ? the most expensive Olympics ever, significantly higher than the $14.3 billion spent by London in 2012.

The ratings agency report said Russia's federal and local governments may have underestimated their World Cup costs because "budgets for large capital projects in Russia have often exceeded initial estimates."

One main reason for this is Russia's rampant corruption, which is particularly high in road construction and other building projects.

Source: http://news.yahoo.com/p-warns-russia-high-costs-2018-world-cup-183848488--finance.html

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John Kerry?s claim that foreign students are ?scared? of U.S. gun violence (Washington Post)

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Wednesday, April 17, 2013

Sympathy for Boston from space

Chris Hadfield / CSA via Twitter

Canadian astronaut Chris Hadfield passed along this picture of Boston at night, as seen from the International Space Station, in recognition of the city's tragedy.

By Alan Boyle, Science Editor, NBC News

Monday's Boston Marathon bombing prompted expressions of sympathy from humanity's farthest-flung outpost: the International Space Station.

"Our crew just heard about the horrible events at the Boston Marathon," the space station's commander, Canadian astronaut Chris Hadfield, wrote in a Twitter update. "We all pass along our condolences and thoughts to everyone affected."

Later, Hadfield tweeted a picture of the city at night in recognition of "a somber spring night in Boston."

Even though the space station wheels around our planet at a height of 230 miles (370 kilometers) or so, the crew stays in touch with earthly news through official NASA communications as well as Internet links that make use of the space agency's TDRS satellite network. For example, the space station has been receiving a digital version of NBC Nightly News for years.

All that altitude gives the station's crew a unique perspective on Earth's tragedies. On Sept. 11, 2001, NASA astronaut Frank Culbertson looked down on the smoke streaming from the wreckage of New York's World Trade Center. "It was like seeing a wound in the side of your country, of your family, your friends," he said years later. Last October, astronauts watched as Superstorm Sandy blasted its way toward the East Coast.

The horrible events in Boston may not have been visible from space?? but Hadfield's tweets demonstrate how we connect during times of tragedy, even when we're off the planet.

More perspectives from space:


Alan Boyle is NBCNews.com's science editor. Connect with the?Cosmic Log?community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other science and space news coverage,?sign up for the Tech & Science newsletter, delivered via email. You can also check out?"The Case for Pluto,"?my book about dwarf planets and the search for new worlds.

Source: http://feeds.nbcnews.com/c/35002/f/653381/s/2ac3e4f7/l/0Lphotoblog0Bnbcnews0N0C0Inews0C20A130C0A40C150C177677910Esympathy0Efor0Eboston0Efrom0Espace0Dlite/story01.htm

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Windows Azure Announces General Availability And Promises To Match Any AWS Price Drop

4578.WindowsAzureLogoMicrosoft has announced general availability for Windows Azure Infrastructure Services with a promise to match any price drop from Amazon Web Services (AWS). Microsoft marked the occasion with a decrease in pricing for cloud services and virtual instances, ranging from 21 to 33 percent. Windows Azure’s infrastructure services have been in preview since last June. Specifically, Azure will match price drops from AWS on commodity services such as compute, storage and bandwidth. Virtual machine instance prices will drop 21% and PaaS will go down by 33 percent. The move is meant to quiet the perception that Azure is more expensive than AWS, said Bill Hilf, general manager of Windows Azure product marketing in an interview yesterday. Hilf that they will also offer new high memory instances of up to 28 and 56 gigabytes to accommodate applications such as Microsoft Sharepoint that just need more memory. Hilf noted that Azure originated as a PaaS cloud, targeting .Net and new apps. Adding IaaS capability allows developers to come to Azure in an easier way, marked by the release last week of Active Directory, which allows for IT to manage identity across Azure and Microsoft environments. Microsoft has consistently added new capabilities over the past several months to its Azure platform. For example, in March, Windows Azure added new support for a number of services including PhoneGap, Dropbox and Hadoop. Like Amazon with AWS, Microsoft does not break out revenues for Azure. He did say that Azure has spun up 1.5 million virtual machines for customers and has 200,000 customers, signing up as of late about 1,000 per day. Hilf said the core differentiator with Amazon and Google is the choice they provide on-premise in the cloud or the combination of the two. Enterprise shops want that capability to enhance their own infrastructure and take advantage of what the cloud offers. The difference for Azure will come down to how well it can convince enterprise customers to use its service over AWS, which had an estimated $1.8 billion in revenues last year and is projected by at least one analyst firm to hit $20 billion in revenues by 2020. AWS has grown so rapidly by giving developers choice and being the go-to service for its massive computational and storage capacity. It has dozens of instance types and consistently drives down its pricing. But success in the enterprise remains elusive for AWS. It has

Source: http://feedproxy.google.com/~r/Techcrunch/~3/zwsmLfF4vEQ/

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White House Calls for Venezuelan Vote Recount (Voice Of America)

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Monday, April 15, 2013

'Avengers' Cast 'Really Proud' Of Big Movie Awards Night

Director Joss Whedon and Earth's mightiest actors weigh in on superhero movie's massive night at the MTV Movie Awards.
By Josh Wigler, with reporting by Josh Horowitz


Chris Evans, Samuel L. Jackson, Tom Hiddleston and Joss Whedon wins at the 2013 MTV Movie Awards
Photo: Kevin Mazur/ WireImage

Source: http://www.mtv.com/news/articles/1705690/avengers-joss-whedon-movie-awards.jhtml

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Irritable Bowel Syndrome | Natural Holistic Health Blog

Are you having problems with your digestion? If it involves the lower half of the digestive tract it could be irritable bowel syndrome. Here are some facts to help you decide.

Irritable bowel syndrome, or IBS, is a condition involving the intestines. There are no clear-cut causes of the condition but it can lead to very painful situations for those affected.

In the intestinal tract, different triggers cause bowels to move differently than they did before. There are usually no visible signs such as inflammation, polyps or tumors that signal that irritable bowel is going on. Those who suffer from IBS often experience abdominal cramping, diarrhea, pain in the abdomen and constipation.

Those who have this condition also deal with bloating and gas. The symptoms may swing from diarrhea to constipation at different times. Doctors can help diagnose it from your description of your symptoms and a physical exam.

Who is at risk for irritable bowel syndrome? Those who have a family history won?t necessarily develop the condition but the odds are not in their favor. It usually occurs in women more than men and young people more so than older adults.

People with certain mental disorders (like depression and psychological trauma) are at risk. Also, those who have experienced abuse in their past, have a greater risk of developing irritable bowel syndrome than others. Fibromyalgia is also a risk factor because it affects the muscles throughout the body.

Once you develop irritable bowel syndrome, you will always have it. Managing the pain involves knowing your triggers and treating the symptoms. Your doctor may perform an endoscopic procedure to look at your intestine and see if something else is going on there that could be causing similar symptoms.

How can you treat the symptoms of IBS? First examine your lifestyle. While there is no direct correlation between food and irritable bowel syndrome, people often experience attacks after they eat. Learning food triggers is one step.

Stress can cause all types of reactions in the body. When it is unmanaged, it can cause gastrointestinal problems. Learning to handle situations in your life that are leading to stress, can reduce its part in the problem.

Exercise helps to bring the body back into optimal health. When the body is receiving proper nutrition and maintains a healthy weight, it is easier for the immune system to fight against illness. Regular physical activity may alleviate some of the symptoms of IBS.

Do you have gastrointestinal problems? See your doctor because you may be suffering from irritable bowel syndrome. While it affects the colon, your symptoms can be controlled through lifestyle changes and medication.

Your doctor may also prescribe medication if diet and exercise don?t make any significant change.

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About Dee Braun

Dee is an Adv. Certified Aromatherapist, Reiki Master, Adv. Color/Crystal Therapist, Herbalist, Dr. of Reflexology and single mom who is dedicated to helping others any way she can. One way she chooses to help is by offering information on the benefits and uses of natural health and healing methods for the well-being of both people and pets. Dee also teaches Aromatherapy, Reflexology and Color/Crystal Therapy at the Alternative Healing Academy

Source: http://www.natural-holistic-health.com/irritable-bowel-syndrome/?utm_source=rss&utm_medium=rss&utm_campaign=irritable-bowel-syndrome

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Got a sec? Clear some Tetris lines on your Pebble

Got a sec Clear some Tetris lines on your Pebble

Put that silly smartphone back in your pocket, Tetris fan! The Pebble e-paper watch is now able to do more than just tell you when you've received a new SMS and play Snake -- a new application called "Pebblis" clones the iconic Russian puzzle game for Pebble with stunning accuracy. Even better? It's free, and super easy to get working. All we had to do with our Android was click through the source link and the Pebble app took care of the rest. Apparently it's a bit tougher to get running via iOS, but then again, Pebblis isn't really an "official" application anyway. And yes, playing Tetris on a watch is pretty difficult. Obviously.

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Source: http://www.engadget.com/2013/04/15/pebblis-pebble/

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Sunday, April 14, 2013

Analysis: Beijing to US on North Korea _ talk

BEIJING (AP) ? Embedded within Chinese leaders' convoluted, yet vague statements to Washington about North Korea is a simple message: Talk with Pyongyang.

U.S. Secretary of State John Kerry's weekend discussions with officials in Beijing offered up the usual encouraging but familiarly noncommittal language on North Korea, emphasizing Beijing's desire to strike a balance between easing tensions on the Korean Peninsula while not appearing to side against its prickly communist ally Pyongyang.

But while neither side offered details of their exchanges, Beijing is communicating its strong desire for some form of direct contact between the U.S. and North Korea as a means of defusing the ongoing crisis over North Korea's nuclear threats that have prompted a massive show of force by the U.S. and South Korea.

"North Korea wants to talk, so why not talk?" said Shen Dingli, a regional security expert and director of the Center for American Studies at Shanghai's Fudan University. The question for China, Shen said, is how to make such discussions come about, adding that China is unlikely to make such calls too explicit for fear of putting either side in an embarrassing quandary.

Highlighting the difficulties of getting North Korea to talk with the U.S., the North rebuffed last week's proposal by Seoul to resolve the tensions through dialogue. North Korea dismissed the proposal as a "crafty trick" to disguise what Pyongyang calls the South's hostility, and said it won't talk unless Seoul abandons its confrontational posture.

Chinese media reports on Kerry's Saturday talks largely downplayed North Korea, and the Foreign Ministry's official statements were predictably blurry. In its account of his meeting with Kerry, the ministry quoted Premier Li Keqiang as referring only to "those who stir up trouble on the peninsula only harm their own interests, like moving a stone only to drop it on one's own foot."

That was a near echo of President Xi Jinping's own comment in a speech earlier this month that "no one should be allowed to throw the region, or even the whole world, into chaos for selfish gains" ? seen as much as a rebuke to the U.S. and its allies as to North Korea's young leader, Kim Jong Un. The ministry's account of Kerry's meeting with Xi didn't mention the Korean Peninsula even obliquely.

While China has grown more critical of North Korea since the latter's third nuclear test in February, Beijing remains highly wary of pushing the hardline communist regime too far. China says it wants a Korean Peninsula free from nuclear weapons, but that all sides must play a role in that.

The stakes are high for China, with a potential conflict threatening its economic development and stability in the northeast along its long, meandering border with North Korea. Beijing abhors the prospect of a pro-U.S. unified Korean state on its border as well as internal North Korean conflict that could spark an outflow of refugees.

China was already displeased by Kim's lack of outreach and lack of concern for Beijing's interests, and signed on to tighter U.N. sanctions following the North's latest nuclear test in February. It's also stepped up customs checks along their border, slowed some deliveries of equipment to the North and cracked down on suspect financial transactions by North Korean banks.

That's had little apparent effect on Kim's behavior, and he seems emboldened by China's lack of a forceful response to past crises and Pyongyang's perceptions of China's fear of a collapse of the regime. While North Korea's population is starving and impoverished, the leadership gets by on Chinese food and fuel, along with growing investment, and imports of North Korean iron ore and other raw materials.

Despite that, it's not clear what, if any, further pressure China is willing to exert, and if Xi, Li or others offered any further commitments, neither side was saying.

"Theoretically, there is more that China can do, but we're very worried that doing so could stimulate Kim to do even more dangerous things," said Shi Yinhong, an international relations expert at Renmin University in Beijing.

"Be prudent, don't go too far" is China's message to Washington and South Korea, Shi said.

While direct Washington-Pyongyang communication may offer a start, the ultimate key to easing tensions long-term lies in involving the other regional players, said Zhang Liangui, a researcher with the ruling Communist Party's main research and training institute in Beijing.

That would mark a return to Beijing's preferred format of six-nation talks involving the two Koreas, China, the U.S., Japan and Russia, a process stalemated since 2009 over how to ensure North Korean compliance with denuclearization measures. Chinese Foreign Minister Wang Yi again communicated Beijing's preference for the Chinese-hosted talks in his Saturday meeting with Kerry.

"This is not an issue for the two sides only," said Zhang, who is close to the Chinese leadership but said he had no direct knowledge of Kerry's meetings. "It concerns the entire region, so all the countries involved should take part."

China is not the only one suggesting a phone conversation between the sides. Flamboyant former NBA player Dennis Rodman made the same point following a bizarre trip to Pyongyang and meetings with Kim in March.

Both Kim and President Barack Obama love basketball "and there is even more they could talk about if Obama would just pick up the phone and call him," Rodman said following the trip.

Source: http://news.yahoo.com/analysis-beijing-us-north-korea-talk-090502853.html

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How Alzheimer's could occur

Friday, April 12, 2013

A new hypothesis has been developed by researchers in Bochum on how Alzheimer's disease could occur. They analysed the interaction of the proteins FE65 and BLM that regulate cell division. In the cell culture model, they discovered spherical structures in the nucleus that contained FE65 and BLM. The interaction of the proteins triggered a wrong signal for cell division. This may explain the degeneration and death of nerve cells in Alzheimer's patients. The team led by Dr. Thorsten M?ller and Prof. Dr. Katrin Marcus from the Department of Functional Proteomics in cooperation with the RUB's Medical Proteome Centre headed by Prof. Helmut E. Meyer reported on the results in the "Journal of Cell Science".

Components of spherical structures in the nucleus identified

The so-called amyloid precursor protein APP is central to Alzheimer's disease. It spans the cell membrane, and its cleavage products are linked to protein deposits that form in Alzheimer patients outside the nerve cells. APP anchors the protein FE65 to the membrane, which was the focus of the current study. FE65 can migrate into the nucleus, where it plays a role in DNA replication and repair. Based on cells grown in the laboratory, the team led by Dr. M?ller established that FE65 can unite with other proteins in the cell nucleus to form spherical structures, so-called "nuclear spheres". Video microscopy showed that these ring-like structures merge with each other and can thus grow. "By using a special cell culture model, we were able to identify additional components of these spheres", says Andreas Schr?tter, PhD student in the working group Morbus Alzheimer at the Institute for Functional Proteomics. Among other things, the scientists found the protein BLM, which is known from Bloom's syndrome ? an extremely rare hereditary disease, which is associated with dwarfism, immunodeficiency, and an increased risk of cancer. BLM is involved in DNA replication and repair in the nucleus.

The amount of FE65 determines the amount of BLM in the cell nucleus

M?ller's team took a closer look at the function of FE65. By means of genetic manipulation, the researchers generated cell cultures, in which the FE65-production was reduced. A smaller amount of FE65 thus generated a smaller amount of the protein BLM in the nucleus. Instead, BLM collected in another area of the cell, the endoplasmic reticulum. In addition, the researchers found a lower rate of DNA replication in the genetically modified cells. In this way, FE65 influences the replication of the genetic material via the BLM protein. When the researchers cranked up the FE65-production again, the amount of BLM in the nucleus also increased again.

FE65 as a possible trigger for Alzheimer's

In patients with Alzheimer's disease, the protein APP, an interaction partner of FE65, changes. The interaction of the two molecules is important for the transport of FE65 into the nucleus, where it regulates cell division in combination with BLM. M?ller's team assumes that the altered APP-FE65 interaction mistakenly sends the cells the signal to divide. Since nerve cells normally cannot divide, they degenerate instead and die. "This hypothesis, which we pursue in the working group Morbus Alzheimer, also delivers new starting points for potential therapies, which are urgently needed for Alzheimer's disease," says Dr. Mueller. In the future, the team will also investigate whether and how the amount of BLM is altered in Alzheimer's patients compared to healthy subjects.

###

Ruhr-University Bochum: http://www.ruhr-uni-bochum.de

Thanks to Ruhr-University Bochum for this article.

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BlackBerry to ask regulators to probe report on returns

TORONTO (Reuters) - BlackBerry plans to ask securities regulators in Canada and the United States to probe what it said is a "false and misleading" report that consumer return rates for its new Z10 smartphone have been high.

The Canadian company, which has pinned its turnaround hopes on its new BlackBerry 10 line of smartphones, went on the offensive on Friday after the report from little known Boston-based research and investment firm Detwiler Fenton sent its stock tumbling on Thursday.

BlackBerry said return rates for its flagship Z10 devices have been at, or below, its forecasts and in line with industry norms.

"To suggest otherwise is either a gross misreading of the data or a willful manipulation," Chief Executive Thorsten Heins said in a statement. "Such a conclusion is absolutely without basis and BlackBerry will not leave it unchallenged."

BlackBerry said Detwiler Fenton had so far refused to share its report or its methods. It said it would present a formal request for an investigation to the U.S. Securities and Exchange Commission and to the Ontario Securities Commission, which is Canada's major securities regulator, over the next few days.

Detwiler Fenton has not returned calls from Reuters seeking comment on its report or on the BlackBerry statement.

"We believe key retail partners have seen a significant increase in Z10 returns to the point where, in several cases, returns are now exceeding sales, a phenomenon we have never seen before," its report said. Detwiler Fenton gave no details on how it had gleaned this information.

TURNAROUND PLAN

BlackBerry is attempting to claw back market share lost to rivals such as Apple Inc's iPhone and Samsung Electronics Co's Galaxy line of smartphones with its new line of devices, powered by the revamped BlackBerry 10 operating system.

The new Z10 touchscreen smartphone, the first of its new devices, hit store shelves earlier this year. And the Q10, with BlackBerry's famed physical keyboard, will go on sale in Canada and the United Kingdom before the end of April.

BlackBerry, which has changed its name from Research In Motion, has yet to prove to the market that its new devices can trigger a turnaround. The company expects to report break-even results in the current quarter, but a true picture will not emerge until later this year.

BlackBerry stock has remained highly volatile as analysts are split on whether the turnaround plan will succeed. Research reports often bring major swings in the company's share price.

Shares of Waterloo, Ontario-based BlackBerry, which fell 7.7 percent on Thursday, were up 1.3 percent at $13.72 by late morning on Friday.

(Reporting by Euan Rocha and Allison Martell; Editing by Janet Guttsman, Bernadette Baum and Peter Galloway)

Source: http://news.yahoo.com/blackberry-ask-regulators-probe-report-returns-124314017--finance.html

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